Pyrrolidine → 1,2,4-Triazolo(3,4-a)phthalazine, 6-(4-methoxyphenyl)-3-(1-pyrrolidinyl)-

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Reaction Steps

A mixture of 6-(4-methoxyphenyl)-3-(methylsulfinyl)-1,2,4-triazolo[3,4-a]phthalazine (3.5 g) and pyrrolidine (30 ml) is heated to 120°/140° C. in a steel bomb for 16 hours. The mixture is then cooled, and the excess of the amine is evaporated off yielding a residue which is washed carefully with a small amount of water and crystallized from 70% ethanol. Yield: 45%. M.p. 196°-98° C.

Provenance & Evidence