Sodium Acetate → HCID 178489106, compound

HRID 2232237Notes

Reaction equation

HRID 2232237 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[N:4]2[N:3]=1.C([O-])(=[O:25])C.[Na+]>C(O)(=O)C>[OH:25][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[N:4]2[N:3]=1

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 7126896-Chloro-3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazine

Product 1

HCID 178489106HCID 178489106, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6-Chloro-3-(4-methoxyphenyl)-1,2,4-triazolo[3,4-a]phthalazine (0.5 mole) and fused anhydrous sodium acetate in acetic acid are heated to the reflux temperature for about 1 hour. The solvent is evaporated under reduced pressure, the residue is then taken up with water, collected by filtration, and crystallized from ethanol/chloroform. The product of the title is thus obtained in a 85% yield. M.p. 307°-309° C.

Workup

  1. temperatureare heated to the reflux temperature for about 1 hour
  2. customThe solvent is evaporated under reduced pressure
  3. filtrationcollected by filtration
  4. customcrystallized from ethanol/chloroform
  5. customThe product of the title is thus obtained in a 85% yield

Sources & evidence

ORD record
ord-18c5feee736f40b189f12b676d4fe1bf
Source dataset
uspto-grants-1988_11
Patent number
US04788186

Reaction notes

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