Water → HCID 54423540, compound

Participants

Reaction Steps

2.5 g (10.4 mmol) of (S)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one in 20 ml of dimethylformamide are stirred at room temperature for 30 minutes with 1.86 g (10.4 mmol) of N-bromosuccinimide. The solution is poured into water and extracted with chloroform. The chloroform extracts are washed several times with water, dried over magnesium sulphate and evaporated. After two-fold recrystallization from ethyl acetate, there is obtained (S)-1-bromo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one of melting point 225°-226°.

Provenance & Evidence