Benzaldehyde → HCID 14100160, compound

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Reaction Steps

In 20 ml of methanol were dissolved 2.570 g of 2,3-diphenyl-5,6-dihydropyrazine, 1.060 g of benzaldehyde and 0.672 g of potassium hydroxide. The solution was heated under reflux for 1 hour. Methanol was removed from the reaction solution by distillation under reduced pressure, and to the residue was added 50 ml of water. The resulting mixture was extracted three times with ethyl acetate. The organic layer from the extraction was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure. The residue thus obtained was subjected to column chromatography on silica gel. A crude product was obtained from the eluates with an 8:1 hexane : ethyl acetate mixture. The crude product was recrystallized from hexane to give 2.940 g of 2,3-diphenyl-5-benzylpyrazine as colorless prisms. M.P. 118°-119° C. Physical properties of the product support a chemical structure of the below formula (VII).

Provenance & Evidence