3-Methoxybenzaldehyde → 2,3-Diphenyl-5-(3-MeOPh)pyrazine

HRID 2232270Notes

Reaction equation

HRID 2232270 reaction equation
[C:1]1([C:7]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:11][CH2:10][CH2:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:19](=O)[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1>CO.O>[C:1]1([C:7]2[C:12]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[N:11][C:10]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=3)=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 115693-MethoxybenzaldehydeHCID 2562185,6-diphenyl-2,3-dihydropyrazine

Product 1

HCID 141001622,3-Diphenyl-5-(3-MeOPh)pyrazine

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

The same procedures as in Example 3 were repeated using 2,3-diphenyl-5,6-dihydropyrazine and m-anisaldehyde. 2,3-Diphenyl-5-(m-methoxybenzyl)pyrazine was obtained as colorless prisms, m.p. 65°-66° C. (recrystallized from methanol-water). Physical properties of the product support a chemical structure of the below formula (IX).

Sources & evidence

ORD record
ord-5af0ed46e5b84675b7738fd516d09820
Source dataset
uspto-grants-1988_11
Patent number
US04788197

Reaction notes

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