2-Thiophenecarboxaldehyde → HCID 14100166, compound

HRID 2232273Notes

Reaction equation

HRID 2232273 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)=[N:13][CH2:12][CH2:11][N:10]=2)=[CH:5][CH:4]=1.[S:23]1[CH:27]=[CH:26][CH:25]=[C:24]1[CH:28]=O>CO>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([C:14]2[C:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)=[N:10][C:11]([CH2:28][C:24]3[S:23][CH:27]=[CH:26][CH:25]=3)=[CH:12][N:13]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 73642-ThiophenecarboxaldehydeHCID 13171292HCID 13171292, compound

Product 1

HCID 14100166HCID 14100166, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same procedures as in Example 3 was repeated using 2,3-bis(p-methoxyphenyl)-5,6-dihydropyrazine and 2-thiophenealdehyde. 2,3-Bis(p-methoxyphenyl)-5-(2-thienylmethyl)pyrazine was obtained as colorless prisms, m.p. 89° C. (recrystallized from methanol). Physical properties of the product support a chemical structure of the below formula (XIII).

Sources & evidence

ORD record
ord-7a5eedfe8aec4111a8b88e3b51ac8b7c
Source dataset
uspto-grants-1988_11
Patent number
US04788197

Reaction notes

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