HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2232277Generated: October 26, 2026
Hydrochloric Acid → 4-[2-(p-Aminophenyl)-ethenyl]-2-aminopyrimidine
https://huagongshe.com/reaction/2232277
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[2-(4-Nitrophenyl)ethenyl]pyrimidin-2-amine | HCID 53791906 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-[2-(p-Aminophenyl)-ethenyl]-2-aminopyrimidine | HCID 53859042 | — |
Reaction Steps
Hydrochloric acid (100 ml of 4N) is added dropwise to a stirred mixture of 4-[2-(p-nitrophenyl)-ethenyl]-2-aminopyrimidine (21.8 g), ethanol (250 ml) and iron filing (22 g). During the addition the reaction temperature is increased to 65° C., and stirring is continued (2 hours) at 65° C. Water is added, followed by an aqueous 30% sodium hydroxide solution (200 ml) and chloroform (1 liter). The chloroform layer is then separated and dried over sodium sulfate. After evaporation and addition of ether, 4-[2-(p-aminophenyl)-ethenyl]-2-aminopyrimidine is obtained (13.5 g), which is used as the starting compound without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04788198 |
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| Source dataset | uspto-grants-1988_11 |
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| ORD ID | ord-efabc60451ab4198b19106a5b5ae4b0e |
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| Source note | uspto-grants-1988_11 |
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