HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic acid dihydrate → HCID 19842243, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic acid dihydrate | HCID 61373 | — |
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | (3-Oxo-2-phenyl-2,3-dihydro-1H-isoindol-1-yl)acetic acid | HCID 14815076 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 19842243 | HCID 19842243 | 83.5% |
Reaction Steps
An oily product (4.3 g), which was prepared from 2.67 g of 3-oxo-2-phenylisoindoline-1-acetic acid and 1.94 g of 1-benzylpiperazine in the same manner as Example 3, was dissolved in 4 ml of methanol, and to this solution a solution of 1.5 g of oxalic acid dihydrate in 6 ml of methanol was added, and the crystals precipitated were collected by filtration. Yield, 4.90 g; m.p., 207°-210° C. (recrystallization from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04788191 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-0c6901bf9d894316a8f62af966ee167b |
| Source note | uspto-grants-1988_11 |