HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Acetylindole → 3-(dimethylamino)-1-(1H-indol-3-yl)prop-2-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Acetylindole | HCID 12802 | — |
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Product | 3-(dimethylamino)-1-(1H-indol-3-yl)prop-2-en-1-one | HCID 1486456 | — |
Reaction Steps
A mixture of 3.18 g of 3-acetylindole and 5.17 ml. (4.36 g) of tert-butoxybis(dimethylamino)methane was heated on a steam bath for 4 hours. The cooled reaction mixture was triturated with n-hexanes and gave a semi-solid. The solvent was removed in vacuo and the material was triturated with dichloromethane giving 3.08 g of the desired compound as a tan crystalline solid, mp 239°-245° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04788195 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-078e9aae25324729b660b8f3c2ad97a3 |
| Source note | uspto-grants-1988_11 |