反应详情

To a solution of 1 millimole of the dimethyl 2,6-dimethyl-4-(4-methylphenyl)-1-[2-(3-furanyl)ethyl]-1,4-dihydropyridine-3,5-dicarboxylate intermediate thus prepared is added under an atmosphere of nitrogen, 3 millimoles of titanium tetrachloride and the mixture stirred overnight at room temperature to obtain the desired dimethyl 4,9,10,10a-tetrahydro-7,10a-dimethyl-9-(4-methylphenyl)-5H-furano[2,3-a]quinolizine-8,10-dicarboxylate product in the reaction mixture. Thereafter, the mixture is diluted with 25 milliliters of chloroform and 25 milliliters of water and the product recovered therefrom in a manner similar to that previously described.

1. additionis added under an atmosphere of nitrogen