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Toluene → 2-(Benzo[b]thiophen-5-yl)-1,3-dioxolane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Benzo(b)thiophene-5-carboxaldehyde | HCID 139097 | — |
| 溶媒 | Ethylene Glycol | HCID 174 | — |
| 生成物 | 2-(Benzo[b]thiophen-5-yl)-1,3-dioxolane | HCID 13922909 | 79% |
反応手順
A solution of product from Step A (16.4 g, 0.1 mol), toluene (300 ml), p-toluenesulfonic acid (1.0 g) and ethylene glycol (20 ml) was heated at reflux with the aid of a Dean-Stark trap. After 6 hours, the organic layer was cooled, washed with saturated Na2CO3. The Na2CO3 layer was extracted with ethyl acetate (2x). The combined organic extracts were dried, filtered and concentrated to dryness. The residue was distilled at 149°-153° C. at 0.3 mm Hg to yield 16.4 g (79%) of product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04788192 |
| 出典データセット | uspto-grants-1988_11 |
| ORD ID | ord-a7a9c28eeef240d3965b16f7ef3748c3 |
| 出典メモ | uspto-grants-1988_11 |