Acetic Anhydride → HCID 21283551, compound

HRID 2232400Notes

Reaction equation

HRID 2232400 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>ClCCl>[N:17]1[CH:18]=[CH:19][C:14]([N:11]2[CH2:12][CH2:13][N:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:20](=[O:22])[CH3:21])=[CH:7][CH:6]=3)[CH2:9][CH2:10]2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 108904611-(4-Aminophenyl)-4-(4-pyridyl)piperazine

Product 1

HCID 21283551HCID 21283551, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1-(4-aminophenyl)-4-(4-pyridyl)piperazine (0.33 g) in a mixture of dichloromethane (20 ml) and acetic anhydride (1.5 ml) was allowed to stand overnight and then evaporated. The residue was triturated with 50 ml of 10% sodium carbonate solution, and then the mixture was diluted to 100 ml with water and extracted several times with chloroform. The combined extracts were dried over sodium sulphate, evaporated and the residue crystallised from ethanol to give the title compound (0.15 g), m.p. 244°-247° C. Found: C,68.82; H,6.67; N,18.69. C17H20N4O requires: C,68.89; H,6.80; N,18.91%.

Workup

  1. customevaporated
  2. customThe residue was triturated with 50 ml of 10% sodium carbonate solution
  3. additionthe mixture was diluted to 100 ml with water
  4. extractionextracted several times with chloroform
  5. dry with materialThe combined extracts were dried over sodium sulphate
  6. customevaporated
  7. customthe residue crystallised from ethanol

Sources & evidence

ORD record
ord-7aa92c2b1a2b47e7bc52df0629efd5df
Source dataset
uspto-grants-1988_11
Patent number
US04788196

Reaction notes

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