反应详情

A solution of sodium cyanate (0.26 g) in water (30 ml) was added over 10 minutes to a stirred solution of 1-(4-aminophenyl)-4-(4-pyridyl)piperazine (0.50 g) in a mixture of acetic acid (20 ml) and water (30 ml). The solution was stirred for 2 hours, allowed to stand for 18 hours and then evaporated. The residue was triturated with water and filtered. The solid was crystallised from N,N-dimethylformamide to give the title compound (0.27 g), m.p. above 250° C. Found: C,64.17; H,6.42; N,23.32. C16H19N5O requires: C,64.62; H,6.44; N,23.55%.

1. waitto stand for 18 hours
2. customevaporated
3. customThe residue was triturated with water
4. filtrationfiltered
5. customThe solid was crystallised from N,N-dimethylformamide