関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 3-Chloro-4-nitropyridine N-oxide | HCID 599817 | — |
| 反応物 | N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride | HCID 18759927 | — |
| 反応物 | N-{4-[4-(4-Aminopyrid-2-yl)piperazin-1-yl]phenyl}methanesulphonamide | HCID 21283535 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | N-{4-[4-(4-Nitro-1-oxidopyrid-3-yl)piperazin-1-yl]phenyl}methanesulphonamide | HCID 21283522 | — |
反応手順
A mixture of N-[(4-piperazin-1-yl)phenyl]methanesulphonamide hydrochloride (the product of Example 11, (iii) (0.59 g), 3-chloro-4-nitropyridine-N-oxide (0.35 g) and sodium bicarbonate (0.50 g) in n-butanol (25 ml) was heated at 100° C. with stirring for 1.5 hours and then evaporated. The residue was stirred with water, filtered, and the solid was crystallised from methanol to give the title compound (0.55 g), m.p. 206°-208° C. Found: C,48.77; H,4.91; N,17.52. C16H19N5O5S requires: C,48.84; H,4.87; N,17.80%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04788196 |
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| 出典データセット | uspto-grants-1988_11 |
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| ORD ID | ord-83eaa1477f2840809921b8537ca37f28 |
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| 出典メモ | uspto-grants-1988_11 |
|---|
