HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 8-Fluoroimidazo(1,2-a)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| Reactant | Acetaldehyde, bromo- | HCID 105131 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Amino-3-fluoropyridine | HCID 2762809 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-Fluoroimidazo(1,2-a)pyridine | HCID 11309538 | — |
Reaction Steps
2-Amino-3-fluoropyridine (21.1 g) is added to a solution of bromoacetaldehyde prepared from 74 g of bromoacetaldehyde diethylacetal, 18.5 ml of aqueous hydrogen bromide solution and 18.5 ml of water and made to react in the presence of sodium bicarbonate in aqueous ethanolic solution giving 12 g of the above-identified compound, bp. 91°-100° C./1-1.5 mmHg, which solidifies at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04788185 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-9dc79665f9f045c297ac41f7132703ea |
| Source note | uspto-grants-1988_11 |