Methyl iodide → HCID 21283735, compound

HRID 2232440Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])[NH:10][N:9]=1.[CH3:23]I>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH3:23])[N:10]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:20])[F:21])[N:12]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 21283745HCID 21283745, compound

Product 1

HCID 21283735HCID 21283735, compound

Procedure

starting from 3-(o-chlorophenyl)-5-(o-trifluoromethyl-phenyl)-1H-1,2,4-triazole and methyl iodide there is obtained a mixture of isomeric N-methyltriazoles and therefrom there are obtained pure 5-(o-chlorophenyl)-1-methyl-3-(o-trifluoromethyl-phenyl)-1H-1,2,4-triazole as a resinous product, 1H-NMR(CDCl3): 3.86 (s, CH3); and pure 3-(o-chlorophenyl)-1-methyl-5-(o-trifluoromethyl-phenyl)-1H-1,2,4-triazole, m.p. 90°-92° C., 1H-NMR(CDCl3): 3.78 (s, CH3);

Workup

customthere is obtained

Sources & evidence

ORD record: ord-6a7e0dfe12d64121bef2a751de23ebbd
Source dataset: uspto-grants-1988_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04788210

Reaction notes

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