1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 131712853, compound

HRID 223245Notes

Reaction equation

HRID 223245 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]([CH2:15][CH2:16][Cl:17])[O:8][CH2:7][C:6]2([CH3:19])[CH3:18].[F:20][C:21]([F:35])([F:34])[C:22]1[CH:23]=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>C(O)CO>[ClH:17].[ClH:17].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]([CH2:15][CH2:16][N:31]1[CH2:30][CH2:29][N:28]([C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([C:21]([F:34])([F:35])[F:20])[CH:23]=3)[CH2:33][CH2:32]1)[O:8][CH2:7][C:6]2([CH3:19])[CH3:18]

Participants

4

Reactant 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 13015779HCID 13015779, compound

Product 1

HCID 131712853HCID 131712853, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

A mixture of 1.50 g. (0.0053 m) of 2-(6,7-dimethoxy-4,4-dimethyisochroman-1-yl)ethyl chloride, 2.48 g. (0.011 m) of 3-trifluoromethylphenylpiperazine and 30 ml of ethylene glycol is stirred at 55° for 24 hr. The mixture is partitioned between methylene chloride and sodium bicarbonate. The organic phase is concentrated and chromatographed. The salt of the title compound is prepared from ethereal hydrogen chloride. The yield is 0.83 g., mp 162°-163.5° C.

Workup

  1. additionA mixture of 1.50 g
  2. customThe mixture is partitioned between methylene chloride and sodium bicarbonate
  3. concentrationThe organic phase is concentrated
  4. customchromatographed

Sources & evidence

ORD record
ord-26b95a0823b144c8969efa7167dc81da
Source dataset
uspto-grants-1982_10
Patent number
US04352805

Reaction notes

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