4-Trifluoromethylnicotinoyl chloride → ethyl N-(4-trifluoromethyl-nicotinoyl)-2-chlorobenzimidate

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Reaction Steps

starting from ethyl o-chlorobenzimidate and 4-trifluoromethyl-nicotinoyl chloride there is obtained ethyl N-(4-trifluoromethyl-nicotinoyl)-2-chlorobenzimidate and therefrom with methylhydrazine there is obtained 3-(o-chlorophenyl)-1-methyl-5-(4-trifluoromethyl-3-pyridyl)-1H-1,2,4-triazole, 1H-NMR(CDCl3): 3.85 (s, N-CH3), 7.6-8.1 (5 aromatic H), 8.9-9.2 (2 aromatic H); mass spectrum: 338 (100), 319 (5), 166 (94), 138 (95);

Provenance & Evidence