HRID2232496

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8100

1,5-Dibromopentane

C5H10Br2

结构：COC(=O)[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1

HCID14308592

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@]1(C)CCc2c(C)c(OCCCCCBr)c(C)c(C)c2O1

HCID14329717

未命名化合物

收率 88.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Using the procedure and molar proportions of example 71, (S)-(-)-6-hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester was alkylated with 1,5-dibromopentane giving (S)-(-)-6-[(5-bromopentyl)oxy]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester, [α]D25 -35.60° (c2, CHCl3), in 88.5% yield.