HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 7-methoxy-4-methyl-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-methyl-2H-1-benzopyran-2-one | HCID 19927689 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-methoxy-4-methyl-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927647 | 77% |
Reaction Steps
Method B (26 h at 50° C.); starting materials: 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-methyl-2H-1-benzopyran-2-one (example 74) and 4-phenylpiperidine; yield 77%; fusion point 141°-143° C. (from isopropanol and ethanol). Fumarate: method E; yield 89%; fusion point 221°-223° C. (from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-139cda73f5df4923b379b1bd496e259a |
| Source note | uspto-grants-1995_06 |