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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2232502Generated: October 25, 2026

Ethyl 2-(3-methoxyphenyl)-4-quinazolinepropionate → N,N-diethyl-2-(3-methoxyphenyl)-4-quinazolinepropanamide

https://huagongshe.com/reaction/2232502

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-(3-methoxyphenyl)-4-quinazolinepropionateHCID 13769245—
SolventDiethylamineHCID 8021—
ProductN,N-diethyl-2-(3-methoxyphenyl)-4-quinazolinepropanamideHCID 1376915655.5%

Reaction Steps

The procedure is as in Example 1, starting with ethyl 2-(3-methoxyphenyl)-4-quinazolinepropionate (1.2 g) and diethylamine (30 cc). After chromatography on silica gel with a cyclohexane/ethyl acetate (1:1 by volume) mixture as eluant, and crystallization in isopropyl ether, N,N-diethyl-2-(3-methoxyphenyl)-4-quinazolinepropanamide (0.36 g), m.p. 87° C., is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04788199
Source datasetuspto-grants-1988_11
ORD IDord-df44d98d76ad43eaa00e3e6254b39df0
Source noteuspto-grants-1988_11