Sodium Carbonate → HCID 13769200, compound

Participants

Reaction Steps

The procedure is as in Example 47, starting with 1-phenyl-3-isoquinolinol (4.4 g), N,N-diethyl-2-chloroacetamide (3.3 g), sodium carbonate (4.25 g) and cuprous iodide (1 g) in 2-butanone (90 cc). After chromatography on silica gel with a chloroform/methanol (98:2 by volume) mixture as eluant and crystallization of the product in isopropyl ether, N,N-diethyl-(1-phenyl-3-isoquinolyl)oxyacetamide (2.6 g), m.p. 105° C., is obtained.

Provenance & Evidence