HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiophenecarboxylic acid → HCID 13769178, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiophenecarboxylic acid | HCID 10700 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | HCID 21283598 | HCID 21283598 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 13769178 | HCID 13769178 | 54.7% |
Reaction Steps
The procedure is as in Example 28, starting with 2-thienoic acid (1.15 g) and thionyl chloride (10 cc), then triethylamine (1.9 cc), N,N-diethyl-3-(2-aminobenzoyl)propanamide (1.11 g) and chloroform (20 cc), and finally ammonium acetate (5 g) and acetic acid (5 cc). After chromatography on silica gel with a cyclohexane/ethyl acetate (1:1 by volume) mixture as eluant and crystallization in isopropyl ether, N,N-diethyl-2-thienyl-4-quinazolinepropanamide (0.83 g), m.p. 106° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04788204 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-cbe014daee814a27a4810e69a24945ef |
| Source note | uspto-grants-1988_11 |