Potassium Iodide → HCID 13078408, compound

Participants

Reaction Steps

A mixture of 4.1 g of 6-methoxy-3-(4-piperidyl)-1,2-benzisoxazole, 3.7 g of 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one, 3.1 g of sodium carbonate, a few crystals of potassium iodide and 125 ml of 2-methyl-4-pentanone was stirred and heated under reflux under nitrogen for 16 hrs. The reaction was poured into 300 ml of water, the layers were separated and the aqueous layer was extracted twice with dichloromethane. The organic layers were combined, washed with water, dried over anhydrous magnesium sulfate and the solvent removed in vacuo to yield an oil. The oil was triturated with ether and the solid was collected. The solid was recrystallized twice from toluene to yield 2.7 g (37.7%) of product, mp 176°-178°.

Provenance & Evidence