Acetic Anhydride → N-(3,4-Difluorophenyl)acetamide

HRID 2232636Notes

Reaction equation

HRID 2232636 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][C:8]=1[F:9]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 774693,4-Difluoroaniline

Product 1

HCID 223109N-(3,4-Difluorophenyl)acetamide

Procedure

To 3,4-difluoroaniline (28.2 g) was added acetic anhydride (30 ml) slowly. After allowed to stand for 30 minutes, the reaction mixture was poured into ice water (100 ml). The resulting precipitate was collected by filtration and washed with water sufficiently to give the title compound (34.7 g) as colorless needles, mp 127°-127.5° C.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with water sufficiently

Sources & evidence

ORD record
ord-c958e0b369de4173be4e7fa470283d27
Source dataset
uspto-grants-1988_11
Patent number
US04788320

Reaction notes

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