Sulfuric Acid → 2,3-Dichloro-4,5-difluorobenzamide

HRID 2232643Notes

Reaction equation

HRID 2232643 reaction equation
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:14]>>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:14]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 140963672,3-Dichloro-4,5-difluorobenzonitrile

Product 1

HCID 140963682,3-Dichloro-4,5-difluorobenzamide

Procedure

A solution of 2,3-dichloro-4,5-difluorobenzonitrile (1.0 g) in concentrated sulfuric acid (2.5 ml) was stirred at 90° to 100° C. for 30 minutes and then cooled. The residue was poured into ice water and the resulting precipitate was collected by filtration and recrystallized from benzene to give the title compound (0.51 g) as colorless needles, mp 153°-155° C.

Workup

  1. temperaturecooled
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from benzene

Sources & evidence

ORD record
ord-83c42384b2eb40df9ff8dc5fc64473f5
Source dataset
uspto-grants-1988_11
Patent number
US04788320

Reaction notes

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