Thionyl Chloride → 3-Bromo-2-chloro-4,5-difluorobenzoyl chloride

HRID 2232652Notes

Reaction equation

HRID 2232652 reaction equation
[Br:1][C:2]1[C:3]([Cl:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:16])=O>>[Br:1][C:2]1[C:3]([Cl:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([Cl:16])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 98383473-Bromo-2-chloro-4,5-difluorobenzoic acid

Product 1

HCID 140717973-Bromo-2-chloro-4,5-difluorobenzoyl chloride

Procedure

A solution of 3-bromo-2-chloro-4,5-difluorobenzoic acid (9.0 g) in thionyl chloride (33 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation to give the title compound (8.8 g), bp 109° C./22 mmHg.

Workup

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation

Sources & evidence

ORD record
ord-43925deb0271466dafbc2cefc4bebbf7
Source dataset
uspto-grants-1988_11
Patent number
US04788320

Reaction notes

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