Hydrochloric Acid → HCID 53834781, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 3,3-dimethyl-4-(4-fluoro-3phenoxybenzyloxy)but-1-ene (0.27 g), p-iodoanisole (0.21 g), palladium (II) diacetate (0.02 g), tri-o-toluylphosphine (0.054 g) and tetramethylethylenediamine (0.1 g) was heated at 160° C. for 24 hours. After cooling, the mixture was poured into dilute aqueous hydrochloric acid, and extracted into ethyl acetate, the extracts combined, washed with water, dried over anhydrous magnesium sulphate, and concentrated by evaporation of the solvent to yield a brown oil. The crude product was distilled through a kugelrohr apparatus to give 3,3-dimethyl-1-(4-methoxyphenyl)-4-(4-fluoro-3-phenoxybenzyloxy)but-1-ene (0.033 g), as an oil, containated by 30% of 3,3-dimethyl-2(4-methoxyphenyl)-4-(4-fluoro-3-phenoxybenzyloxy)but-1ene.

Provenance & Evidence