Benzoyl chloride → 2-Dimethylaminoethyl benzoate

HRID 223271Notes

Reaction equation

HRID 223271 reaction equation
[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][OH:5].[C:7](Cl)(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>C(Cl)(Cl)Cl>[C:7]([O:5][CH2:4][CH2:3][N:2]([CH3:6])[CH3:1])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 79022-(Dimethylamino)ethanolHCID 14798Sodium Hydroxide

Product 1

HCID 751582-Dimethylaminoethyl benzoate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In accordance with the procedure of Example 10, 89.1 g of 2-dimethylaminoethanol and 140.5 g of benzoyl chloride are reacted in altogether 300 ml of CHCl3. The reaction mixture is neutralised with 210 ml of 20% NaOH. Yield: 187.7 g (97.1%) of analytically pure product (analysis by gas chromatography) with a boiling point of 127° C./9 torr.

Sources & evidence

ORD record
ord-57021d546e714894b0e3088a554dfde4
Source dataset
uspto-grants-1982_10
Patent number
US04352913

Reaction notes

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