HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 3,3-Bis(3-chlorophenyl)-2-propenal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | Diethyl chlorophosphate | HCID 13139 | — |
| Reactant | 3,3'-Dichlorobenzophenone | HCID 348303 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | N-Ethylidene-2-methylpropan-2-amine | HCID 138901 | — |
| Product | 3,3-Bis(3-chlorophenyl)-2-propenal | HCID 14547227 | — |
Reaction Steps
The compound was prepared according to the procedure described in Example 84. The following reagents were used: 3,3'-dichlorobenzophenone (25.1 g), diisopropylamine (32.2 mL), 1.6M n-butyl lithium in hexane (144 mL), acetaldehye N-tertbutylimine (14.75 mL), diethyl chlorophosphonate (16.6 mL) and tetrahydrofurane (200 mL). The usual work up furnished 24.0 g of essentially pure 3,3-bis(3-chlorophenyl)-2-propenal as an orange oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04788206 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-43311cba43f94a1ea0a4c62ee103da3c |
| Source note | uspto-grants-1988_11 |