Butyl isocyanate → HCID 20523358, compound

HRID 223276Notes

Reaction equation

HRID 223276 reaction equation
[CH2:1]([N:5]=[C:6]=[O:7])[CH2:2][CH2:3][CH3:4].[C:8]([CH:10]([CH3:19])[CH2:11][NH:12][CH2:13][CH2:14][CH2:15][N:16]([CH3:18])[CH3:17])#[N:9]>C(Cl)Cl>[CH2:1]([NH:5][C:6]([N:12]([CH2:11][CH:10]([C:8]#[N:9])[CH3:19])[CH2:13][CH2:14][CH2:15][N:16]([CH3:18])[CH3:17])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 8110Butyl isocyanateHCID 20341589HCID 20341589, compound

Product 1

HCID 20523358HCID 20523358, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Under nitrogen, a solution of 99.1 g of butyl isocyanate in 100 ml of methylene chloride is added dropwise in the course of 1 hour to a solution of 169.3 g of N-(β-cyanopropyl)-dimethylaminopropylamine in 500 ml of methylene chloride. The mixture is then refluxed for 2 hours, concentrated, and the residue is treated at 80° C. in a high vacuum in order to remove all low boiling constituents. Yield: 249.2 g (90.8%) of product in the form of an oil. Titration: 1 equivalent=261.9 g (theory 268.4 g).

Workup

  1. temperatureThe mixture is then refluxed for 2 hours
  2. concentrationconcentrated
  3. additionthe residue is treated at 80° C. in a high vacuum in order
  4. customto remove all low boiling constituents

Sources & evidence

ORD record
ord-1af98f98a08e4c6687899fd98bc3e442
Source dataset
uspto-grants-1982_10
Patent number
US04352913

Reaction notes

Loading…