HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-{3-[4-(4-chlorophenylmethyl)-1-piperazinyl]-propoxy}-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 1-[(4-Chlorophenyl)methyl]-4-(3-chloropropyl)piperazine | HCID 13399727 | — |
| Reactant | 6-hydroxy-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one | HCID 19927715 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-{3-[4-(4-chlorophenylmethyl)-1-piperazinyl]-propoxy}-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one | HCID 19927675 | 74% |
Reaction Steps
Method D (5 h at 90° C.); starting materials: 6-hydroxy-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one (example 103) and 1-[(4-chlorophenyl)methyl]-4-(3-chloropropyl)piperazine; yield: 74%; fusion point 96°-97° C. (from isopropanol and petroleum ether). Hydrochloride (x 2 HCl): method G; yield 95%; fusion point 255°-260° C. (from isopropanol and water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-a4995629b6204d468d5b4336e14f9897 |
| Source note | uspto-grants-1995_06 |