Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 14347270, compound

Participants

Reaction Steps

As described in Example 99, (E)-3-(4-methoxyphenyl)-3-(3- pyridinyl)-2-propenal (5.25 g was reacted with (carbomethoxymethylene)triphenylphosphorane (7.4 g) in dichloromethane (40 mL) for 17 hours at room temperature. The crude ester was isolated in the usual way and was purified by HPLC to give 4.6 g of the ester. A portion was crystallized twice from ether-hexane to give the analytical sample of (E,E)-5-(4-methoxyphenyl)-5-(3-pyridinyl)-2,4-pentadienoic acid methyl ester, mp 75°-76° C.

Provenance & Evidence