Sodium Hydroxide → HCID 14347268, compound

Participants

Reaction Steps

In the manner described in Example 99, (E,E)-5-(4-methoxyphenyl)-5-(3-pyridinyl)-2,4-pentadienoic acid methyl ester (0.295 g) was saponified in a refluxing mixture of methanol (1.5 mL) and 1N NaOH 1.5 mL). After the cooled reaction was neutralized with 1N HCI (1.5 mL), the crude acid was filtered off and crystallized from methanol to afford 0.235 g of (E,E)-5-(4-methoxyphenyl)-5-(3-pyridinyl)-2,4-pentadienoic acid as its 0.33 molar hydrate, mp 173°-175° C. Anal. Calcd for C17H15NO3 0.33 H2O: C, 71.08: H, 5.49:, N, 4.88. Found: C, 71.01: H, 5.59: N, 4.85.

Provenance & Evidence