Sodium Hydroxide → HCID 14347277, compound

Participants

Reaction Steps

In the manner described in Example 99, (2E,4Z)-5-(4-methoxyphenyl)-5-(2-thienyl)-2,4-pentadienoic acid methyl ester (4.7 g) was saponified in a refluxing mixture of methanol (20 mL) and 2N NaOH (20 mL). After the cooled reaction was worked up in the usual manner, the crude acid was crystallized from 2-propanol to provide 3.4 g of (2E,4Z)-5-(4-methoxyphenyl) -5-(2-thienyl)-2,4-pentadienoic acid, mp 214°-216° C.

Provenance & Evidence