Sodium Hydroxide → HCID 14347283, compound

HRID 2232816Notes

Reaction equation

HRID 2232816 reaction equation
C[O:2][C:3](=[O:22])/[CH:4]=[CH:5]/[CH:6]=[C:7](\[CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)/[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1.[OH-].[Na+]>CO>[CH:16]1(/[C:7](/[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:6]\[CH:5]=[CH:4]\[C:3]([OH:22])=[O:2])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86742575HCID 86742575, compound

Product 1

HCID 14347283HCID 14347283, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

As described in Example 99, (E,E)-5-cyclohexyl-5-(4-methoxyphenyl)-2,4-pentadienoic acid methyl ester (5.9) was saponified in a refluxing mixture of methanol (20 mL) and 2N NaOH (20 mL). After 2 hours the reaction was worked up in the normal manner, and the crude was crystallized from cyclohexane-hexane to give 3.37 g of (E,E)-5-cyclohexyl-5-(4-methoxyphenyl)-2,4-pentadienoic acid, mp 130.5°-131.5° C.

Workup

  1. customthe crude was crystallized from cyclohexane-hexane

Sources & evidence

ORD record
ord-5855d7419ffd4e498f76e902adcd97f1
Source dataset
uspto-grants-1988_11
Patent number
US04788206

Reaction notes

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