Sodium Hydroxide → HCID 14347285, compound

Participants

Reaction Steps

As described in Example 99, (E,E)-5-(4-methoxyphenyl)-2,4-hexadienoic acid methyl ester (6.8 g) was saponified in a refluxing mixture of methanol (30 mL) and 2N NaOH (30 mL). After 2.5 hours the reaction was worked up in the normal manner to give 6.1 g of (E,E)-5-(4-methoxyphenyl)-2,4-hexadienoic acid. Crystallization of a portion from 2-propanol furnished the analytical sample, mp 174°-177° C.

Provenance & Evidence