Sodium Hydroxide → HCID 14347289, compound

Participants

Reaction Steps

As described in Example 99, (E,E)-5-(4-methoxyphenyl)-6-methyl -2,4-heptadienoic acid methyl ester (4 g) was saponified in a refluxing mixture of methanol (15 mL) and 2N NaOH (15 mL). After 2 hours reaction was worked up in the usual way and the crude acid was crystallized from cyclohexane-hexane to provide 2.8 g of (E,E)-5-(4-methoxyphenyl)-6-methyl-2,4-heptadienoic acid, mp 140.5°-141.5° C.

Provenance & Evidence