Sodium Hydroxide → HCID 14347305, compound

Participants

Reaction Steps

As described in Example 99, (2E,4Z)-5-(3-fluorophenyl)-2,4-decadienoic acid methyl ester (6.1 g) was saponified in a refluxing mixture of methanol (40 mL) and 2N NaOH (30 mL). After 1 hour the crude acid was isolated in the usual way and crystallized from ether-hexane to give 4.1 g of (2E,4Z)-5-(3-fluorophenyl)-2,4-decadienoic acid, mp 100.5°-101° C.

Provenance & Evidence