Methanol → HCID 21282941, compound

Participants

Reaction Steps

α-[(1-Oxo-3,3-diphenylpropyl)amino]-3,4-dimethoxybenzenepropionic acid, methyl ester (6.0 g) in 1N sodium hydroxide, tetrahydrofuran, and methanol was allowed to stir at room temperature for several hours. The mixture was evaporated to 50% volume and poured into ethyl acetate and water. The layers were separated and the aqueous layer was brought to pH 2 using concentrated hydrochloric acid. The mixture was extracted with ethyl acetate (2×50 ml) and the combined extracts were washed with water, brine, dried over magnesium sulfate, filtered and evaporated at reduced pressure.

Provenance & Evidence