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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2232899Generated: October 31, 2026

1-Iodopropane → 4-(4-Chloro-3-trifluoromethyl-phenyl)-1-propyl-piperidine

https://huagongshe.com/reaction/2232899

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-IodopropaneHCID 33643—
Reactant4-[4-Chloro-3-(trifluoromethyl)phenyl]piperidineHCID 16679317—
Product4-(4-Chloro-3-trifluoromethyl-phenyl)-1-propyl-piperidineHCID 9904611—

Reaction Steps

Beginning with 4-(4-Chloro-3-trifluoromethyl-phenyl)-piperidine and 1-propyliodide, the title compound was re-covered by the procedure described in Example 2. m.p. 218-220° C. (HCl), MS m/z (rel. intensity, 70 eV) 305 (M+, 4), 278 (35), 277 (13), 276 (bp), 70 (40).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUSRE041315E1
Source datasetuspto-grants-2010_05
ORD IDord-0a0f9f0f11e44a66aa7372175e6c0475
Source noteuspto-grants-2010_05