HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chloropropyl)-4-phenylpiperidine → 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-(trifluoromethyl)-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chloropropyl)-4-phenylpiperidine | HCID 203689 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 6-hydroxy-7-methoxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one | HCID 19927739 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-(trifluoromethyl)-2H-1-benzopyran-2-one | HCID 19927695 | 45% |
Reaction Steps
Method D (3 h at 85° C.); starting materials: 6-hydroxy-7-methoxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one (example 104) and 1-(3-chloropropyl)-4-phenylpiperidine; yield 45%; fusion point 125°-126° C. (from TBME and methanol). Fumarate: method E; yield 59%; fusion point 176°-179° C. (from ethanol and TBME).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-ee803333f37a47e09dae10cb3370c666 |
| Source note | uspto-grants-1995_06 |