1-Chloro-2-iodo-4-(trifluoromethyl)benzene → 4-(2-Chloro-5-trifluoromethyl-phenyl)-1-propyl-piperidin-4-ol

HRID 2232937Notes

Reaction equation

HRID 2232937 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1I.[CH2:13]([N:16]1[CH2:21][CH2:20][C:19](=[O:22])[CH2:18][CH2:17]1)[CH2:14][CH3:15]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[C:19]1([OH:22])[CH2:20][CH2:21][N:16]([CH2:13][CH2:14][CH3:15])[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 695961-Chloro-2-iodo-4-(trifluoromethyl)benzeneHCID 900061-Propyl-4-piperidone

Product 1

HCID 223451614-(2-Chloro-5-trifluoromethyl-phenyl)-1-propyl-piperidin-4-ol

Procedure

Beginning with 4-chloro-3-iodobenzotrifluoride and 1-propyl-4-piperidone, the titled compound was recovered by the procedure described in Preparation 4, MS m/z (rel. intensity, 70 eV)) 321 (M+, 8), 294 (38), 292, (bp), 274 (52), 56 (35).

Workup

  1. customthe titled compound was recovered by the procedure
  2. customdescribed in Preparation 4, MS m/z (rel. intensity, 70 eV)) 321 (M+, 8), 294 (38), 292, (bp), 274 (52), 56 (35)

Sources & evidence

ORD record
ord-b16965b79860415e9f91c2e53d4a853a
Source dataset
uspto-grants-2010_05
Patent number
USRE041315E1

Reaction notes

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