Phenylhydrazine hydrochloride → 1-[2-chloro-3-(trifluoromethyl)phenyl]-5-(2-methylbenzyl)-1H-1,2,4-triazole
Reaction equation
Cl.[Cl:2][C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[NH:13][NH2:14].Cl.[C:16]1(NN)C=CC=CC=1.[CH:24]([NH:26][C:27](=O)[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=O>>[Cl:2][C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[N:13]1[C:27]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[CH3:16])=[N:26][CH:24]=[N:14]1Participants
Procedure
The title compound was prepared using the procedure as described in Example 80 substituting 2-chloro-3-trifluoromethylphenylhydrazine hydrochloride for phenylhydrazine hydrochloride and substituting Example 76A for N-formylphenylacetamide. The residue was purified by flash chromatography (20% ethyl acetate/hexanes) to provide the title compound. MS (ESI) m/e: 352 (M+H); 1H NMR (DMSO-d6) δ 2.05 (s, 3H), 4.05 (s, 2H), 6.7-6.75 (d, 1H), 6.85-6.96 (m, 1H), 7.04-7.1 (d, 2H), 7.7-7.75 (t, 1H), 7.89-7.97 (d, 1H), 8.05-8.1 (d, 1H), 8.18 (s, 1H); Anal. calcd. for C: 58.05, H: 3.73, N: 11.95. Found C, 58.10; H, 3.86; N, 11.68. The title compound (0.12 g, 0.34 mmol) in ethyl acetate (3 mL) was treated with 1 M HCl/diethyl ether (5 mL). After stirring for 1 hour, the mixture was diluted with diethyl ether, filtered, and the filter cake was dried under high vacuum to provide the title compound as a hydrochloride salt. MS (ESI) m/e: 352 (M+H)+; 1H NMR (DMSO-d6) δ 2.05 (s, 3H), 4.05 (s, 2H), 6.7-6.75 (d, 1H), 6.85-6.96 (m, 1H), 7.04-7.1 (d, 2H), 7.7-7.75 (t, 1H), 7.89-7.97 (d, 1H), 8.05-8.1 (d, 1H), 8.18 (s, 1H); Anal. calcd. for C, 52.60; H, 3.63; N, 10.82. Found C, 52.54; H, 3.42; N, 10.79.
Workup
- customThe title compound was prepared
- customThe residue was purified by flash chromatography (20% ethyl acetate/hexanes)
Sources & evidence
- ORD record
- ord-021fa9e48467409d986ee6a5499b428f
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709469B2
Reaction notes
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