Water → HCID 70502606, compound

HRID 223299Notes

Reaction equation

HRID 223299 reaction equation
[CH3:1]C(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O.[OH:14][C@@H:15]1[CH2:32][CH2:31][C@@:30]2([CH3:33])[C@H:17]([CH2:18][CH2:19][C@@H:20]3[C@@H:29]2[C@H:28]([NH:34][C:35]([O:37][CH2:38][C:39]([Cl:42])([Cl:41])[Cl:40])=[O:36])[CH2:27][C@@:25]2([CH3:26])[C@H:21]3[CH2:22][CH2:23][C@@H:24]2[C:43]([OH:45])=[O:44])[CH2:16]1.O>CC(C)=O>[O:14]=[C:15]1[CH2:32][CH2:31][C@@:30]2([CH3:33])[C@@H:17]([CH2:18][CH2:19][C@@H:20]3[C@@H:29]2[C@H:28]([NH:34][C:35]([O:37][CH2:38][C:39]([Cl:42])([Cl:41])[Cl:40])=[O:36])[CH2:27][C@@:25]2([CH3:26])[C@H:21]3[CH2:22][CH2:23][C@@H:24]2[C:43]([O:45][CH3:1])=[O:44])[CH2:16]1

Participants

5

Reactant 3

HCID 962WaterHCID 12804583HCID 12804583, compoundHCID 131709961Jones' reagent

Product 1

HCID 70502606HCID 70502606, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Jones reagent was added dropwise to a stirred solution of the product of Preparation 3 (0.3 g) in acetone (20 ml) until the reagent colour was not discharged. Water (150 ml) was added and the precipitate obtained was collected by filtration, washed with water, dried and crystallised from ethyl acetate/petrol to give the title compound (0.19 g), m.p. 208°-209° C., [α]D +41°.

Workup

  1. customthe precipitate obtained
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried
  5. customcrystallised from ethyl acetate/petrol

Sources & evidence

ORD record
ord-d0619cde7b424841982d435e4591cfa6
Source dataset
uspto-grants-1982_10
Patent number
US04352798

Reaction notes

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