HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl methyl ether → 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-propyl-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-propyl-2H-1-benzopyran-2-one | HCID 19927738 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-propyl-2H-1-benzopyran-2-one | HCID 19927725 | 54% |
Reaction Steps
Method A (20 h at 60° C.); starting materials: 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-propyl-2H-1-benzopyran-2-one (example 76) and 4-phenylpiperidine; yield 54%; fusion point 101°-102° C. (from TBME and petroleum ether). Fumarate: method E; yield 62%; fusion point 191°-194° C. (from acetone and methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-f6916d529fe9473aa2dc8d74fbd0b5a2 |
| Source note | uspto-grants-1995_06 |