HCID 68676946, compound → HCID 68675905, compound

Participants

Reaction Steps

A solution of 160 mg of the product of Step A in 1,4-dioxane (5.0 mL) and 6N NaOH (1.0 mL) was warmed to 50° C. After three days, the solvents were removed and the residue was dissolved in water and extracted with chloroform. The pH of the aqueous layer was adjusted to 3 with 2N HCl and then extracted with 9:1 chloroform/IPA (3×). The organic extracts were washed with sat. sodium chloride solution, dried over sodium sulfate, filtered, and concentrated to afford 2-(2-tert-butyl-8-isopropylamino-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)-2-methyl-propionic acid as a white solid. MS (M+H+)=336.4.

Provenance & Evidence