Hydrochloric Acid → HCID 68675905, compound

Participants

Reaction Steps

To a solution of 400 mg of methyl 2-(2-tert-butyl-8-isopropylamino-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)-2-methyl-propionate in dioxane (10.0 mL) was added 6.0 N KOH (1.0 mL) and the mixture was heated at reflux for 16 h. The reaction mixture was cooled to ambient temperature, diluted with water, the pH was adjusted to 2.0 with 6.0 N HCl, and the mixture was extracted with EtOAc (2×). The organic extracts were dried over magnesium sulfate, filtered, and concentrated to leave 2-(2-tert-butyl-8-isopropylamino-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)-2-methyl-propionic acid as a white solid. MS (M+H+)=336.3.

Provenance & Evidence