HCID 68675905, compound → HCID 68676622, compound

HRID 2233025Notes

Reaction equation

HRID 2233025 reaction equation
[C:1]([N:5]1[C:23](=[O:24])[N:8]2[CH:9]=[C:10]([C:17](C)([CH3:21])[C:18](O)=O)[N:11]=[C:12]([NH:13][CH:14]([CH3:16])[CH3:15])[C:7]2=[N:6]1)([CH3:4])([CH3:3])[CH3:2]>CC(O)=O>[C:1]([N:5]1[C:23](=[O:24])[N:8]2[CH:9]=[C:10]([CH:17]([CH3:21])[CH3:18])[N:11]=[C:12]([NH:13][CH:14]([CH3:15])[CH3:16])[C:7]2=[N:6]1)([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 1

HCID 68675905HCID 68675905, compound

Product 1

HCID 68676622HCID 68676622, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 300 mg of the product of Step A in AcOH (5.0 mL) was heated at reflux for two h. The solvent was removed to afford 2-tert-butyl-6-isopropyl-8-isopropylamino-2H-[1,2,4]triazolo[4,3-a]pyrazin-3-one as a light green solid. A suspension of 240 mg of this product and 329 mg of aluminum trichloride in dichloroethane (10.0 mL) was heated at reflux for two h. The reaction was poured into water and the resulting solution was extracted with EtOAc. The organic extract was dried over magnesium sulfate, filtered, and concentrated and the residue was purified by silica gel chromatography to afford the title compound as an off-white solid. MS (M+H+)=234.1.

Workup

  1. temperatureat reflux for two h
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-1eea46b38ba04897a915186aea979e34
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

Loading…