Hydrochloric Acid → HCID 68675380, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 400 mg of the product of Step A in 1,4-dioxane (10 mL) was treated with 6N KOH (2.0 mL) and the mixture was heated at 60° C. for three h. The reaction was cooled to ambient temperature, diluted with water, and the pH adjusted to 2 with 2N HCl. The mixture was extracted with EtOAc and the organic layer was dried over MgSO4, filtered, and concentrated to afford 1-(2-tert-butyl-8-isopropylamino-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)-cyclopentanecarboxylic acid as a white solid. MS (M+H+)=360.3.

Provenance & Evidence